Table 1.

Referential experimental studies used to develop the network. E1 represents gain of function (GoF) and KO stands for LoF of the corresponding molecules.

Stimulus/Perturbations	Model Response/Phenotype	Cell Lines	References
miR-34a in the absence of DNA Damage	Proliferation	A549, H460	[36]
miR-34a in the presence of DNA Damage	Triggers senescence and apoptosis	A549, H460	[36]
miR-34a Vs c-Myc in response to DNA Damage	Negative correlation	A549, H460	[36]
miR-34a E1	Induces Senescence and Apoptosis	A549, H460	[36]
c-Myc KO	Activating Senescence and Apoptosis	A549, H460	[36]
miR-16 E1 and RB E1	Induces Senescence and Apoptosis	A549	[37]
miR-16 E1 and RB KO	Induces only Apoptosis	A549	[37]
miR-16 E1	Activating Senescence and Apoptosis	A549	[37]
miR-449a Vs C-Met in response to DNA Damage	Negative correlation	A549	[38]
miR-449a KO	Proliferation	A549	[38]
miR-449a E1	Induces Senescence and Apoptosis	A549	[38]
C-Met KO	Activating Senescence and Apoptosis	A549	[38]
miR-34a E1 and miR-16 E1	Activating Senescence and Apoptosis	A549	[39]
miR-34a E1 and RB E1	Induces Senescence and Apoptosis	A549	[39]
miR-34a KO and miR-16 KO	Induces only Apoptosis	A549	[39]
RB E1	Induces Senescence and Apoptosis	A549	[39]
miR-34a KO and miR-449a KO	Proliferation	A549	[40]
miR-34a E1 and miR-449a E1	Induces Senescence and Apoptosis	A549	[40]
miR-449a Vs lncRNA XIST in DNA Damage Response	Negative correlation	A549, H460	[14]
miR-449a E1	Activating Senescence and Apoptosis	A549, H460	[14]
lncRNA XIST KO	Induces Senescence and Apoptosis	A549, H460	[14]
miR-16 Vs lncRNA XIST in DNA Damage Response	Negative correlation	A549	[15]
miR-16 E1	Triggers senescence and apoptosis	A549	[15]
lncRNA XIST KO	Induces Senescence and Apoptosis	A549	[15]