Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 8;10(4):575. doi: 10.3390/vaccines10040575

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Histopathological Findings from Endomyocardial Biopsies. Hematoxylin-eosin stains of heart-tissue specimens showed inflammatory infiltrates composed of mononuclear cells with foci of severe interstitial edema and multifocal cardiomyocyte damage consistent with the diagnosis of definitive acute myocarditis (Panels A and B). Immunostaining demonstrated predominant inflammatory infiltration of lymphocytes (Panel C, CD3 immunostaining for T-lymphocytes, and Panel D, CD20 immunostaining for B-lymphocytes) and, to a lesser extent, macrophages (Panel E, CD68 immunostaining). A repeated endomyocardial biopsy 3 months later showed a complete resolution of myocarditis without evidence of inflammation or cardiomyocyte damage (Panel F, hematoxylin-eosin stains). Original magnification, ×200; scale bars, 100 µm (Panels A, and D–F) and original magnification, ×400; scale bars, 50 µm (Panel B).