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. 2022 Apr 11;19(8):4564. doi: 10.3390/ijerph19084564

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ISRIB inhibited UPR signaling pathways and ER stress. TM4 cells were treated by ISRIB at the concentration of 200, 400 nM for 6 h before treated by FLC at the concentration of 160 μM for 6 h. UPR and apoptosis related protein levels were determined by Western Blot with indicated antibodies. (a) The representative blots were shown; (b) The quantitative data was analyzed by ImageJ and GraphPad Prism software. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. corresponding group, n = 6.

ISRIB inhibited UPR signaling pathways and ER stress. TM4 cells were treated by ISRIB at the concentration of 200, 400 nM for 6 h before treated by FLC at the concentration of 160 μM for 6 h. UPR and apoptosis related protein levels were determined by Western Blot with indicated antibodies. (a) The representative blots were shown; (b) The quantitative data was analyzed by ImageJ and GraphPad Prism software. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. corresponding group, n = 6.