Table 1.

Factors that may contribute to sarcopenia in children with solid organ tumors.

Direct Factors	Indirect Factors
Reduced physical activity Medications − Chemotherapy − Doxorubicin − Cisplatin − Steroid use Radiation Cancer cachexia − Tumor inflammation − Organ dysfunction − Pain/stress Endocrine − Peptide ghrelin − Vitamin D	Fatigue Chemotherapy − Mucositis − Nausea and Vomiting − Diarrhea