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(a) Schematic representation of CuPRiXX with a detailed structure of DOTAGA(Gd) and uncomplexed DOTAGA groups; (b) HPLC-UV chromatograms of CuPRiX1 and CuPRiX2 (10 µL, 100 g/L) recorded at 295 nm; (c) Hydrodynamic diameter distribution in volume obtained by dynamic light scattering; (d) Zeta potential vs. pH for CuPRiX1 and CuPRiX2; (e) Comparison of the amount of DOTA groups between CuPRiX1 and CuPRiX2 based on their unchelated DOTAGA measurements.
