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. 2022 Apr 7;14(4):814. doi: 10.3390/pharmaceutics14040814

Figure 4.

Figure 4

Effect of AGuIX® (800 µM of DOTAGA(Gd)) and CuPRiX2 (800 µM of DOTAGA(Gd) and 500 µM of uncomplexed DOTAGA) on LOX activity in (a) A549 and (b) SQ20B-CSCs cells. Cells were treated for 24 h and 48 h and the activity of LOX (an extracellular copper-dependent enzyme) in the culture medium was assessed. LOX activity levels are relative to background noise (blank control). Data are presented as mean ± SD (n = 2) with 2 technical replicates for each experiment. ** p < 0.01, *** p < 0.001, two-way ANOVA.