Table 4.
Characteristics of infants with MIS-N and MIS-C belonging to cohort studies and not fully described.
| First Author | Total Number of Children with MIS-C | Number of Infants under Six Months of Age | Available Description |
|---|---|---|---|
| Abdel-Haq [46] |
13 | 1 | A 3-months-old girl with a positive RT-PCR for SARS-CoV-2 and dilated coronary arteries, successfully treated with IVIG and infliximab |
| Alharbi [47] |
5 | 2 | Full description in Table 3 (Case 2 and Case 3) |
| Antúnez-Montes [48] | 95 | 3 | 3 infants under the age of a month, but their specific clinical characteristics were not described |
| Caro-Domínguez [49] | 37 | 1 | A 6-months-old boy with cardiac failure and positive RT-PCR for SARS-CoV-2 |
| Chandran [50] |
17 | 3 | Two infants survived (a 1-month-old infant who had prematurity as comorbidity and a 6-months-old infant who had previously undergone Kasai procedure at 2 months of age for biliary atresia). A 1-month-old infant with refractory thrombocytopenia and multiorgan involvement, treated with IVIG, methylprednisolone and cyclosporine, died. |
| Dufort [51] |
191 | 1 | A neonate with MIS-N, born to a positive mother (asymptomatic at delivery) who presented with fever and left breast cellulitis between 14 and 28 days of age. Laboratory work-up showed increasing troponin levels; echocardiogram showed good ventricular function and unremarkable coronary arteries. Two molecular tests for SARS-CoV-2 were negative. The discharge diagnoses were cellulitis, myocarditis, and shock. |
| Godfred-Cato [54] |
85 | 1 | The specific clinical characteristics of infants < 6 months of age are not described. |
| Grewal [55] |
92 | 9 | Nine infants under the age of 6 months, none with acute kidney injury. |
| Güllü [56] |
320 | 3 | A 1-month-old girl, followed up with aortic coarctation, resulted to be positive for SARS-CoV-2 and had fever and poor feeding. A 3-months-old boy, followed up with ventricular septal defect and pulmonary hypertension, had fever, diarrhoea (leading to a severe dehydration and lack of urine). A 6-days-old boy, who applied with fever, vomiting, decreased feeding and respiratory distress for 2 days. It was learned that his aunt and grandfather had been diagnosed with COVID-19 and they had loved and cared for the baby. |
| Mehra [57] |
120 | 1 | Among four deaths, one was a 3-month-old infant with acute COVID-19 related severe acute respiratory distress syndrome and shock |
| Niño-Taravilla [58] |
26 | 2 | Two neonates with MIS-C (the specific clinical characteristics are not described) |
| Shaiba LA [44] |
36 | 2 | Full description in Table 3 (Case 30 and Case 31) |