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. 2022 Apr 15;23(8):4391. doi: 10.3390/ijms23084391

Figure 8.

Figure 8

Effect of the phosphorous dendrimer G4 on NMDA-induced (a) caspase 9, (b) caspase 3, and (c) caspase 12 enzymatic activity in brain organoids. Brain organoids were treated with either vehicle (V) or G4 phosphorous dendrimer (10 µM) for 1 h, and then NMDA (150 µM) was added. Caspase 3 and 9 activities were determined at 3 h and caspase 12 at 6 h. Caspase activity was determined in total lysates as described in the Materials and Methods section. The data are expressed as the mean + the s.e.m. of five independent experiments. ** p < 0.01, *** p < 0.001 as compared to NMDA-treated cells in the absence of dendrimers.