TABLE 3.
Alterations in the GyrA and ParC proteins in 35 N. gonorrhoeae strains
| Pattern | Amino acid substitutions in:
|
No. of strains | CIPa MIC (μg/ml) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GyrA
|
ParC
|
|||||||||
| Ser-91 (TCC) | Asp-95 (GAC) | Asp-86 (GAC) | Ser-87 (AGT) | Ser-88 (TCC) | Glu-91 (GAG) | Tyr-104 (TAT) | Leu-131 (CTC) | |||
| M1 | Phe (TTC) | 1 | 8 | |||||||
| M2 | Phe (TTC) | Gly (GGC) | Leu (CTG) | 2 | 4–8 | |||||
| M3 | Phe (TTC) | Ala (GCC) | Asn (AAT) | 1 | 4 | |||||
| M4 | Tyr (TAC) | Gly (GGC) | Asn (AAC) | 1 | 8 | |||||
| M5 | Phe (TTC) | Gly (GGC) | Asn (AAC) | 3 | 8 | |||||
| M6 | Phe (TTC) | Gly (GGC) | Pro (CCC) | 1 | 8 | |||||
| M7 | Phe (TTC) | Gly (GGC) | Lys (AAG) | 1 | 16 | |||||
| M8 | Phe (TTC) | Asn (AAC) | Asn (AAC) | Leu (CTG) | 3 | 4–8 | ||||
| M9 | Phe (TTC) | Gly (GGC) | Asn (AAC) | Leu (CTG) | 11 | 8 | ||||
| M10 | Phe (TTC) | Gly (GGC) | Lys (AAG) | Leu (CTG) | 1 | 32 | ||||
| M11 | Phe (TTC) | Gly (GGC) | Asn (AAT) | Lys (AAG) | 8 | 8–16 | ||||
| M12 | Phe (TTC) | Asn (AAC) | Asn (AAC) | Pro (CCC) | Leu (CTG) | 1 | 4 | |||
| M13 | Phe (TTC) | Gly (GGC) | Arg (CGT) | Tyr (TAC) | Leu (CTG) | 1 | 16 | |||
a
CIP, ciprofloxacin.