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. 2022 Apr 12;14(8):1947. doi: 10.3390/cancers14081947

Figure 1.

Figure 1

Reduced ECM deposition in tumors from mice lacking PDGFB in platelets. (A) Mice lacking PDGFB in the platelet/megakaryocyte lineage were generated using the Cre-loxP recombination system, with Cre expressed under the PF4 promoter. (B–E) Sections of tumor tissue from 14-week old WT and pl-PDGFB KO RT2-positive mice were immunostained for (B,C) collagen 1 (WT n = 11; KO n = 14, * p = 0.0280) and (D,E) fibronectin (WT n = 11; KO n = 11, * p = 0.0207) and the positive areas quantified using Image J. Expression of collagen 1 (Col1;WT n = 11; KO n = 11, * p = 0.0336) (F) and fibronectin (FN; WT n = 11; KO n = 11, * p = 0.1464) (G) were analyzed by qPCR in tumors from 14-week old WT and pl-PDGFB KO RT2-positive mice. Error bars in the graphs represent the standard error of mean (SEM).