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. 2022 Apr 12;14(8):1947. doi: 10.3390/cancers14081947

Figure 2.

Figure 2

Reduced PDGFB levels in tumors from mice lacking PDGFB in platelets. (A) PDGFB is released from activated platelets in the TME in WT mice, but not in pl-PDGFB KO mice. (B) The amount of PDGFB protein in tumors derived from 14-week old WT and pl-PDGFB KO RT2-positive mice was analyzed using PEA in tissue lysates from whole tumors (WT n = 3; KO n = 3, * p = 0.0300). (C) Expression of PDGFB was analyzed by qPCR using RNA extracted from whole tumors from 14-week old WT and pl-PDGFB KO RT2-positive mice (WT n = 11; KO n = 10, p = 0.6776 (ns)).