FIG. 7.

Comparison of viable counts and bioluminescence (measured by ICCD camera) with administration of different doses of ceftazidime (CAZ; 50, 20, and 5 mg/kg) (A), tetracycline (TET; 30, 10, and 1 mg/kg) (B), and ciprofloxacin (CIP; 30, 10, and 1 mg/kg) (C) in the neutropenic-mouse thigh model of infection. Viable counts and bioluminescence were determined at 0 and 8 h for each dose of antibiotic and for infection controls (IC). The correlation between viable- cell count and bioluminescence is 0.98, 0.94, and 0.91 for ceftazidime (A), tetracycline (B), and ciprofloxacin (C), respectively. Each data set is the mean ± SE determined using two animals.