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Localization of EC14(pCGLS1.UC) in the neutropenic-mouse thigh model. A bacterial suspension of 105 cells/thigh was injected intramuscularly, and images were acquired with the ICCD camera at 0, 4, and 8 h. Infection control animals are shown in panel A, while panel B illustrates the antibacterial effects of a 50-mg/kg treatment with ceftazidime administered IP at 1 and 5 h postinfection. A similar bit range of 0 to 3 was used to display each image.
