TABLE 2.

Comparison of viable-cell counts and bioluminescence analysis in determining ceftazidime treatment differences in the mouse thigh model of infection^a

Analytical methods (no. of animalsb)	Time period (h)	Log mean difference between treatment groups ± SE	P value between treatment groupsc	Least significant log difference among treatment groups
Viable-cell plate counts—two-way ANOVA (28)	8	2.8 ± 0.21	2.0E-09	0.44
	12	3.6 ± 0.18	9.0E-12	0.38
ICCD camera—two-way ANOVA (28)	8	2.1 ± 0.19	2.0E-08	0.41
	12	2.0 ± 0.16	7.0E-09	0.35
ICCD camera—repeated-measures ANOVA (8)	8	1.5 ± 0.17	3.0E-09	0.34
	12	2.0 ± 0.17	1.0E-11	0.34

^aData used for this statistical analysis were derived from experiments represented in Fig. 4 and 6. 

^bThe animals from the 0-h time point are not included here as no treatment difference would be seen. 

^cP values, determined using JMP software, indicate significant differences between ceftazidime-treated and untreated control groups.