Table 2.
Clinical and embryological parameters after vaginal administration of Gns.
| All | AMH < 0.5 (Group A) |
0.5 ≤ AMH < 1.2 (Group B) |
AMH ≥ 1.2 (Group C) |
F | p Value | Post Hoc | |
|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Bonferroni | |||
| Injection number | 3.0 ± 0.9 | 3.0 ± 0.9 | 3.1 ± 0.7 | 3.0 ± 0.7 | 0.495 | 0.610 | |
| Days of hCG | 10.4 ± 2.8 | 10.2 ± 3.0 | 10.9 ± 2.2 | 10.3 ± 2.1 | 1.380 | 0.253 | |
| Total dose Gn | 1318.4 ± 634.4 | 1343.1 ± 661.3 | 1291.9 ± 637.0 | 1191.6 ± 414.1 | 0.721 | 0.487 | |
| AFC (numbers) | 2.8 ± 2.2 | 2.2 ± 1.6 | 3.4 ± 2.2 | 6.0 ± 2.7 | 49.376 | <0.001 * | C > B > A |
| hCGd follicle 9–11/total follicle | 0.282 ± 0.257 | 0.287 ± 0.275 | 0.265 ± 0.222 | 0.269 ± 0.185 | 0.174 | 0.840 | |
| hCGd follicle 12–15/total follicle | 0.327 ± 0.286 | 0.316 ± 0.310 | 0.323 ± 0.227 | 0.406 ± 0.210 | 1.152 | 0.318 | |
| hCGd follicle 16–21/total follicle | 0.392 ± 0.278 | 0.397 ± 0.295 | 0.412 ± 0.233 | 0.325 ± 0.239 | 0.933 | 0.395 | |
| hCGd Endometrium thickness | 8.553 ± 2.640 | 8.346 ± 2.676 | 9.314 ± 2.544 | 8.172 ± 2.276 | 2.836 | 0.061 | |
| Oocyte_total | 3.0 ± 2.3 | 2.4 ± 1.6 | 3.63 ± 2.1 | 6.0 ± 3.6 | 39.212 | <0.001 * | C > B > A |
| Oocyte_mature | 2.2 ± 1.9 | 1.8 ± 1.4 | 2.4 ± 1.8 | 4.2 ± 3.3 | 23.700 | <0.001 * | C > B, C > A |
| Oocyte_immarture | 0.8 ± 0.98 | 0.6 ± 0.7 | 1.2 ± 1.2 | 1.7 ± 1.2 | 26.976 | <0.001 * | C > B > A |
| 2PN | 1.6 ± 1.6 | 1.2 ± 1.3 | 2.1 ± 1.7 | 3.1 ± 1.8 | 21.919 | <0.001 * | C > B > A |
| Good embryos | 0.9 ± 1.0 | 0.7 ± 0.9 | 1.3 ± 1.3 | 2.0 ± 1.5 | 18.420 | <0.001 * | C > B > A |
| Total egg/embryos frozen | 0.560 ± 1.067 | 0.600 ± 0.979 | 0.434 ± 1.201 | 0.556 ± 1.368 | 0.496 | 0.609 | |
| Number_fresh ET # | 0.8 ± 1.0 | 0.7 ± 0.9 | 1.1 ± 0.9 | 1.7 ± 1.2 | 15.212 | <0.001 * | C > B > A |
| Clinical pregnancy (%) # | 18.1% | 15.1% | 20.8% | 33.3% | |||
| Live birth (%) # | 16.7% | 16.3% | 12.2% | 26.1% | 0.355 | ||
| OSI | 767.1 ± 579.1 | 835.9 ± 588.2 | 746.0 ± 608.0 | 397.6 ± 263.9 | 6.707 | 0.001 * | B > C, A > C |
| FORT | 1.0 ± 0.8 | 0.9 ± 0.7 | 1.2 ± 1.1 | 0.9 ± 0.6 | 2.957 | 0.054 | |
| FOI | 1.3 ± 1.0 | 1.3 ± 1.0 | 1.4 ± 1.2 | 1.1 ± 0.5 | 1.038 | 0.356 |
Abbreviations: AMH: anti-Müllerian hormone; hCG: human chorionic gonadotropin; Gn: gonadotropin; AFC: antral follicle counts; hCGd: day of human chorionic gonadotropin injection; 2 PN: two pronuclei; ET: embryo transfer; OSI: ovarian sensitivity index, the dose of rhFSH used divided by the number of mature oocytes obtained; FORT: follicular output rate, the ratio of preovulatory follicle count (14–22 mm in diameter) on hCG day 100/small antral follicle count (3–8 mm in diameter) at baseline; FOI: follicle to oocyte index, the ratio between the number of oocytes obtained and the number of antral follicles at the beginning of COS. All data presented as mean ± SD, except categorical variables. Statistical analysis was performed by one-way ANOVA followed by Bonferroni’s post hoc tests. Group A: AMH < 0.5 ng/mL; Group B: 0.5 ng/mL ≤ AMH < 1.2 ng/mL; Group C: AMH ≥ 1.2 ng/mL. * p< 0.05. #: indicates per oocyte retrieval.