TABLE 3.

Values of population pharmacokinetic parameters for acyclovir from data for patients younger than age 2 years receiving the drug by the oral route^a

Model and value	θ1	θ4 (liters)	θ5 (h−1)	b	θ2 (mo)	θ3	Var (ηCL)	Var (ηV)	Var (ηka)	ς2
Fixed effects
Estimate	25.5	37.0	0.277	0.760	13.4	6.17
SEb	2.9	5.3	0.018	0.066	0.58	0.60
Random effects
Estimate							0.245	0.324	2.98 × 10−8	0.210
SE							0.051	0.222	1.97 × 10−3	0.050

^aθ₁, θ₃, and b are dimensionless parameters. See text for definitions of θ₁ to θ₅. 

^bSE, standard error of estimate.