Figure 4.

The plotted mode of action-relevant chemical patterns of the isolated compounds (DKPs 1–11 (black), and 12 (dark blue)), and the clinical chemotherapeutic agents searched from the ChEMBL database (alkylating agents (green, 19 compounds), anti-metabolites (orange, 21 compounds), proteasome inhibitors (yellow, 4 compounds), tyrosine kinase inhibitors (pink, 74 compounds), topoisomerase inhibitors (brown, 3 compounds), and anti-microtubule agents (light blue, 642 compounds)). The score plot was marked with three dimensions (principal components) including PC1 (red) describing the size, shape, and polarizability; PC2 (blue) representing the aromatic- and conjugation-related properties; and PC3 (yellow) depicting lipophilicity, polarity, and H-bond capacity. The overall view (A) and the individual views (B) of the analytical results.