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. 2001 Jan;45(1):158–165. doi: 10.1128/AAC.45.1.158-165.2001

TABLE 6.

Metabolism of DAPD in human PBMCs and CEM cells incubated with 5 μM DAPDa

Cell type Intracellular concn (pmol/106 cells)
DAPD DXG DXG-MP DXG-DP DXG-TP
PBMCs 0.54 3.93 Blb Bl Bl
CEM cells 0.02 2.30 0.07 0.04 0.46
a

Cells were incubated for 24 h with 5 μM [5′-3H]DAPD (specific activity, 9.4 Ci/mmol). MP, monophosphate; DP, diphosphate. 

b

Bl, below the limit of detection of 0.01 pmol/106 cells.