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. 2022 Apr 17;23(8):4431. doi: 10.3390/ijms23084431

Figure 5.

Figure 5

Effect of Dio on the activation of TLR4-MyD88-NF-κB signaling pathway and immune-inflammation status in rats with CDDP-induced mucositis. Changes in the relative protein expression levels of TLR4 (A), MyD88 (B), p-NF-κB/NF-κB ratio (C) and p-IκBα/IκBα ratio (D). (E) Representative Western blotting images of TLR4, MyD88, p-NF-κB, NF-κB, p-IκBα and IκBα. (F) Relative mRNA expression of TLR4, MyD88, NF-κB and IκBα. Changes in the relative protein expression levels of TNFα (G), Pro-IL1β & IL1β (H), IL6 (I) and IL10 (J). (K) Representative Western blotting images of TNFα, Pro-IL1β, IL1β, IL6 and IL10. (L) Relative mRNA expression of TNF-α, IL-1β, IL-6 and IL-10. * p < 0.05, ** p < 0.01 vs. control group, # p < 0.05, ## p < 0.01 vs. CDDP group.