Table 1.

Serum PIIINP concentrations in patients with heart failure.

Authors	Heart Failure Type	Main Findings
Alla et al. [32]	HF vs. HHD with T2DM vs. HC	PIIINP levels were higher in HF and HHD with T2DM than HC PIIINP levels were higher in HF than HHD with T2DM
Barasch et al. [58]	HFrEF vs. HFpEF	Associated with HFrEF and HFpEF
Cicoira et al. [52]	HFmrEF, single arm	Decreased survival with PIIINP > 4.7 μg/L
Martos et al. [51]	HFpEF, single arm	Increased PIIINP
Plaksej et al. [63]	HF vs. HC	Increased levels in NYHA class III and IV
Zannad et al. [50]	HFrEF, single arm	Decreased survival with PIIINP > 3.85 μg/L
Zile et al. [59]	HHD and HFrEF vs. HC	Elevated PIIINP
Klappacher et al. [47]	DCM vs. HC	Decreased survival with PIIINP > 7 μg/L
Fassbach et al. [64]	HCM vs. HC	Increased PICP in patients with HCM
Michalski et al. [61]	HFrEF vs. HFpEF	Strong negative correlation of PIIINP with LV strains
Multi-Ethnic Study of Atherosclerosis (MESA) [62]	HFrEF vs. HFpEF	Elevated PIIINP
Nagao et al. [49]	Acute HF, single arm	High PIIINP did not correlate with significant excess risk for outcome
Sato et al. [53]	DCM, single arm	Elevated PIIINP levels associated with decreased survival rate
Poulsen et al. [54]	HF vs. HC	Increased PIIINP level > 5 μg/L is an independent predictor of cardiac death and in-hospital development of HF
Nikolov et al. [55]	HFmrEF vs. HC	Increased PIIINP
Schwartzkopff et al. [60]	DCM vs. HC	Independent predictors of mortality

NYHA, New York Heart Association; DCM, dilated cardiomyopathy; HF, heart failure not specified by ejection fraction; HFrEF, heart failure with reduced ejection fraction; HFmrEF, heart failure with mid-range ejection fraction; HFpEF, heart failure with preserved ejection fraction; HC, healthy control; T2DM, type 2 diabetes mellitus.