Figure 4.
High-resolution images of the collagen VI extracellular matrix. Representative images (blue = nuclei, green = collagen VI matrix) of fibroblasts from healthy controls (A) and from the four individuals (1–4, B–E, respectively) showing collagen VI globular speckles (arrows), often connected by thin fibrils, a diffuse staining pattern and general fragmentation of collagen VI fibrils in individual samples compared with an organized network of fibers from a healthy control.