Figure 1.

Schematic presentation of the experiment setup. (A) Each pig (n = 10) received 6 wounds on its back, 4 of which were treated with resiquimod, and 2 of which remained untreated as control wounds. Control and resiquimod-induced wounds were randomly arranged on the back of each pig to avoid a location bias. (B) The entire duration of the experiment was 16 days, during which the animals were anesthetised twice and received a sedation once. Resiquimod application lasted for 6 days. Dressing changes were performed on a daily basis, as were visual scoring and documentation. Biopsies for gene expression analysis were collected on days 1, 7 and 16, and biopsies for histology were collected only on day 16.