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. 2022 Apr 6;10(4):856. doi: 10.3390/biomedicines10040856

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Resiquimod-induced inflammation increased the expression of IL6, MMP1, CD68, IL8 and COX-2. Relative mRNA expression levels of CD68, COX-2, IL10, IL8, IL6, MMP1, TGFb and INFg were determined by qPCR, normalising target gene expression to the averaged expression of YWHAZ. Resiquimod-induced wounds (grey) were compared to control wounds (black). Data are presented as mean (bar) + standard deviation (whiskers) (n = 9–12 for controls and 17–24 for resiquimod application). Data shown as mean + SD. Statistical significance has been determined by 2-way ANOVA and corrected for multiple comparisons using the Sidak method. * (p < 0.05), ** (p < 0.01).