Figure 7.

Short-term resiquimod application promotes the release of cytokines in the dermis. Release of cytokines into dISF was analysed by OFM. Split-thickness wounds were inflicted and treated with resiquimod and, 48 h later, OFM probes were implanted to sample dISF. Total IL8, IL6, TNFalpha and IL1b content was measured (n = 6–12 per treatment). Data are shown as mean ± SD. Statistical significance was determined by unpaired t-test with a Welch’s correction. * (p < 0.05), ** (p < 0.01), **** (p < 0.0001).