Table 3.

Various combinations of active pharmaceutical ingredients in bilayer tablets.

Drugs	Dosage Form	Form Rational	Year	Ref. No
Metformin HCl Evogliptin tartrate	Bilayer tablets	Synergistic effect in diabetes	2021	[25]
Metformin HCl Dapagliflozin l-proline	Bilayer tablets	Synergistic effect in diabetes	2021	[27]
Trimetazidine HCl, Clopidogrel bisulphate	Bilayer tablets	Cytoprotective anti-ischemic, platelet inhibitor in acute coronary syndromes	2014	[28]
Metformin HCl, Glimipiride	Bilayer tablets	Synergistic effect in diabetes	2011	[29]
Metformin HCl Atorvastatin Calcium	Bilayer tablets	To develop polytherapy for the treatment of NIDDS and hyperlipidemia	2011	[30]
Piracetam Vinpocetine	Bilayer tablets	Synergistic effect in Alzheimer disease	2011	[31]
Trihexyphenidyl HCl Ziprasidone HCl.	Bilayer floating tablets	For extending the metabolism and improving the bioavailability of both APIs; simultaneous administration of antipsychotics and anticholinergics to prevent or treat extrapyramidal syndrome (EPS)	2011	[26]
Cefixime Trihydrate, Dicloxacillin Sodium	Bilayer tablets	Synergistic effect in bacterial infections	2011	[32]
Amlodipine besylate, Metoprolol Succinate	Bilayer tablets	Synergistic effect in hypertension	2009, 2011	[33,34]
Diclofenac Sodium, Paracetamol	Bilayer tablets	Synergistic effect in pain	2010	[35]
Atenolol, Lovastatin	Bilayer floating tablets	Synergistic effect in hypertension and biphasic release profile	2009	[36]
Montelukast, Levocetrizine	Bilayer tablets	Improvement of the stability of drugs in combination	2009	[37]
Salbutamol Theophylline	Bilayer tablets	Synergistic effect of drugs in asthma	2009	[38]
Rifampicin, Isoniazid	Capsule and tablet in capsule	To avoid interaction b/w incompatible drugs	2007	[39]
Ranitidine, Aspirin	Single-layer coated tablets	Minimizing the contact of two incompatible drugs	2003	[40]
Misoprostol, Diclofenac	Bilayer tablets	To minimize contact b/w drugs	2007	[41]