Table 5.
Alcohol exposure caused fetal anemia which iron supplementation resolved.
| CON | ALC | CON + Iron | ALC + Iron | p Value | |||
|---|---|---|---|---|---|---|---|
| ALC | Iron | ALC × Iron | |||||
| RBC (×106 cells/μL) | 1.65 ± 0.13 ab | 1.47 ± 0.18 b | 1.67 ± 0.12 a | 1.64 ± 0.14 ab | 0.039 | 0.058 | 0.141 |
| Hemoglobin (g/dL) | 10.2 ± 0.6 a | 10.0 ± 0.5 a | 10.5 ± 0.4 a | 10.5 ± 0.6 a | 0.596 | 0.044 | 0.490 |
| Hematocrit (%) | 31.4 ± 2.1 ab | 28.5 ± 3.0 b | 31.8 ± 1.7 a | 31.2 ± 2.3 ab | 0.037 | 0.056 | 0.162 |
| MCV (fL/cell) | 190.6 ± 3.3 | 194.4 ± 4.5 | 190.7 ± 3.5 | 190.6 ± 2.8 | 0.138 | 0.138 | 0.123 |
| MCH (pg/cell) | 62.2 ± 4.6 | 69.0 ± 10.5 | 62.8 ± 5.3 | 64.1 ± 4.3 | Overall p = 0.225 | ||
| MCHC (pg/dL) | 32.6 ± 1.9 | 35.4 ± 4.5 | 32.9 ± 2.2 | 33.6 ± 1.9 | Overall p = 0.273 | ||
| PLT (×103 cells/μL) | 135.4 ± 20.3 | 122.7 ± 15.7 | 140.4 ± 23.9 | 130.9 ± 23.2 | 0.126 | 0.360 | 0.818 |
| RDW-CV (%) | 14.9 ± 0.8 ab | 14.1 ± 1.1 b | 15.1 ± 0.7 ab | 15.6 ± 0.9 a | 0.541 | 0.012 | 0.052 |
| MPV (fL/cell) | 12.0 ± 0.5 a | 12.4 ± 0.4 a | 11.9 ± 0.3 a | 12.2 ± 0.3 a | 0.011 | 0.061 | 0.565 |
| ZnPP (μmol ZnPP/mol heme) | 65.4 ± 8.7 a | 59.0 ± 4.2 a | 59.2 ± 3.7 a | 61.9 ± 6.4 a | 0.396 | 0.479 | 0.043 |
| nRBC (per 100 WBCs) | 907 ± 397 a | 1153 ± 241 ab | 768 ± 393 a | 1985 ± 1384 b | 0.001 | 0.556 | 0.102 |
Values are means ± SD. n = 8–9 litters per group. Means that do not share a common superscript letter differ at p < 0.05. Significant p-values are bolded. ALC, alcohol exposed; CON, control; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; nRBC, nucleated red blood cell count per 100 WBCs; PLT, platelet count; RBC, red blood cell count; RDW-CV, red blood cell distribution width coefficient of variation; WBC, white blood cell count; ZnPP, zinc protoporphyrin.