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Interaction of neuropathic OPs with NTE. The hydroxyl group at the active site serine reacts with the phosphorus atom of the OP, resulting in the phosphorylation of NTE and the dephosphorylated OP (X). During the aging reaction, an R group from the phosphate moiety of NTE is released, resulting in a negative charge. Due to the aging reaction not being reversible, this results in the permanent inhibition of NTE’s esterase activity.
