Figure 3.
The genetic deletion of OATP1B2 increases venetoclax exposure. (A) Plasma concentration curves of venetoclax in female wild-type DBA or OATP1B2(−/−) mice administered venetoclax (10 mg/kg; PO) (n = 10/group). Serial plasma samples were collected from each mouse and analyzed via LC-MS/MS. (B) Maximum concentration (Cmax) and (C) area under the concentration-time curve (AUC) using the last observed timepoint (AUC0–8h) calculated with non-compartmental analysis (NCA) using Phoenix WinNonlin 8.1., ** p < 0.01, *** p < 0.001.