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Factors that have been identified in peer -reviewed journals as contributing to hIAPP aggregation. This can occur due to change of concentrations of different molecules (HSPGs, Zn2+ IL-1β, Aβ, alpha synuclein) that directly or indirectly interact with hIAPP as part of various metabolic mechanisms (molecular chaperones, and through conditions linked with T2DM (hyperglycaemia, ER stress).
