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. 2001 Jan;45(1):187–195. doi: 10.1128/AAC.45.1.187-195.2001

TABLE 2.

Efficacy of selected compounds against four reference strains of P. falciparum DHFR

DHFR allele	IC₅₀ (μM) of compound:
DHFR allele	Pyrimethamine	WR99210	26	43	70	72	77	80
S108	0.007	0.01	ND^a	0.5	ND	0.017	ND	4.4
N51I + S108N	0.07	0.06	ND	3.0	ND	0.05	ND	7.2
C59R + S108N	0.07	0.06	ND	4.4	ND	0.08	ND	9.5
N51I + C59R + S108N + I164L	>10	0.07	>10	>10	10.0	2.9	3.7	>10

^a

ND, not determined.