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Elevating SOX2 downregulates MYC protein and mRNA in multiple tumor types. (A) Western blot analysis of MYC protein levels in i-SOX2 tumor cell lines after 48 h culture in the presence or absence of Dox at the indicated concentrations. (B) RT-qPCR analysis of MYC mRNA expression in i-SOX2 tumor cell lines after 48 h culture in the presence or absence of Dox at the indicated concentrations. Error bars represent standard deviation. * p < 0.05, *** p < 0.001.
