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. 2022 Apr 12;14(8):1946. doi: 10.3390/cancers14081946

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SOX2 and MYC regulate ribosomal biogenesis and protein translation genes in ONS76 cells. (A) Venn diagram showing the overlap of MYC-bound genes in ONS76 cells, i-SOX2-ONS76 DEGs, and i-Omomyc-ONS76 DEGs. (B) Percentage of MYC-bound genes differentially expressed in i-SOX2-ONS76, i-Omomyc-ON76, or both, based on the location of the MYC-binding peak. (C) TOP 10 GO Transcription Factor (ENCODE and CHEA) and Biological Process enrichment categories for common genes bound by MYC and differentially expressed in i-SOX2-ONS76 and i-Omomyc-ONS76 cells.