TABLE 1.

Comparative in vitro activities of L-036 and reference drugs against clinical isolates

Organism (no. of strains)	Drug	MIC (μg/ml)a
		Range	50%	90%
Staphylococcus aureus
Methicillin-susceptible strains (43)	L-036	≤0.063	≤0.063	≤0.063
	Faropenem	≤0.063–0.25	0.125	0.25
	Imipenem	≤0.063	≤0.063	≤0.063
	Levofloxacin	0.125–1	0.25	0.5
	Cefditoren	0.5–4	1	1
	Cefdinir	0.25–4	0.5	0.5
	Amoxicillin	0.25–64	4	16
Methicillin-resistant strains (39)b	L-036	≤0.063–8	4	8
	Faropenem	0.125–>128	128	>128
	Imipenem	0.063–64	32	64
	Levofloxacin	0.125–>128	8	128
	Cefditoren	4–>128	64	128
	Cefdinir	0.125–>128	64	128
	Amoxicillin	8–128	64	64
Staphylococcus epidermidis
Methicillin-susceptible strains (34)	L-036	≤0.063–1	≤0.063	0.125
	Faropenem	≤0.063–0.5	0.125	0.5
	Imipenem	≤0.063–0.125	≤0.063	0.125
	Levofloxacin	0.125–8	0.25	4
	Cefditoren	0.125–2	0.5	2
	Cefdinir	≤0.063–2	0.125	1
	Amoxicillin	0.125–8	0.5	2
Methicillin-resistant strains (30)b	L-036	0.5–8	2	8
	Faropenem	≤0.063–>128	2	>128
	Imipenem	0.25–64	4	64
	Levofloxacin	0.25–128	4	16
	Cefditoren	2–128	16	64
	Cefdinir	0.125–>128	16	128
	Amoxicillin	1–64	8	32
Streptococcus pneumoniae
Penicillin-susceptible strains (66)	L-036	0.0005–0.032	0.002	0.032
	Faropenem	0.004–0.25	0.008	0.25
	Imipenem	0.002–0.25	0.008	0.125
	Levofloxacin	0.25–2	0.5	1
	Cefditoren	0.008–0.5	0.063	0.5
	Cefdinir	0.016–8	0.25	4
	Amoxicillin	0.008–0.5	0.032	0.5
Penicillin-resistant strains (32)c	L-036	0.032–0.5	0.063	0.125
	Faropenem	0.25–4	0.5	2
	Imipenem	0.25–2	0.25	1
	Levofloxacin	0.5–1	1	1
	Cefditoren	0.25–4	0.5	1
	Cefdinir	2–64	8	16
	Amoxicillin	1–8	2	4
Enterococcus faecalis (35)	L-036	0.25–2	0.5	2
	Faropenem	0.5–8	1	4
	Imipenem	8–>128	128	>128
	Levofloxacin	1–64	1	64
	Cefditoren	0.5–>128	32	>128
	Cefdinir	0.5–>128	4	64
	Amoxicillin	0.5–1	0.5	1
Enterococcus faecium (45)	L-036	2–>128	64	128
	Faropenem	4–>128	128	>128
	Imipenem	8–>128	128	>128
	Levofloxacin	1–128	16	64
	Cefditoren	64–>128	>128	>128
	Cefdinir	64–>128	>128	>128
	Amoxicillin	0.5–>128	64	64
Escherichia coli (42)	L-036	≤0.063	≤0.063	≤0.063
	Faropenem	0.125–2	0.5	0.5
	Imipenem	≤0.063–0.25	0.125	0.125
	Levofloxacin	≤0.063–64	≤0.063	8
	Cefditoren	≤0.063–1	0.25	0.5
	Cefdinir	≤0.063–1	0.125	0.5
	Amoxicillin	0.5–>128	4	>128
Klebsiella pneumoniae (34)	L-036	≤0.063–0.5	≤0.063	≤0.063
	Faropenem	0.25–4	0.5	0.5
	Imipenem	0.125–0.5	0.25	0.25
	Levofloxacin	≤0.063–4	≤0.063	0.25
	Cefditoren	≤0.063–64	0.25	0.5
	Cefdinir	≤0.063–128	0.125	0.25
	Amoxicillin	1–>128	64	>128
Haemophilus influenzae (38)	L-036	≤0.063–0.5	≤0.063	0.25
	Faropenem	0.125–4	0.5	1
	Imipenem	0.25–16	1	4
	Levofloxacin	≤0.063	≤0.063	≤0.063
	Cefditoren	≤0.063–0.25	≤0.063	≤0.063
	Cefdinir	0.25–4	0.5	2
	Amoxicillin	0.5–32	0.5	32
Legionella pneumophila (11)	L-036	≤0.063	≤0.063	≤0.063
	Faropenem	≤0.063	≤0.063	≤0.063
	Imipenem	≤0.063	≤0.063	≤0.063
	Levofloxacin	≤0.063	≤0.063	≤0.063
	Cefditoren	0.25–16	8	16
	Cefdinir	0.25–8	8	8
	Amoxicillin	≤0.063–1	0.5	1
Moraxella catarrhalis (34)	L-036	≤0.063	≤0.063	≤0.063
	Faropenem	≤0.063–1	0.25	0.5
	Imipenem	≤0.063–0.125	≤0.063	≤0.063
	Levofloxacin	≤0.063	≤0.063	≤0.063
	Cefditoren	≤0.063–0.5	0.25	0.5
	Cefdinir	0.125–0.5	0.25	0.5
	Amoxicillin	≤0.063–8	2	4

^a50% and 90%, MICs at which 50 and 90% of isolates were inhibited, respectively. 

^bOxacillin MIC, ≥4 μg/ml. 

^cAmoxicillin MIC, ≥one μg/ml.