TABLE 2.
Therapeutic efficacy of L-084 and reference drugs in murine respiratory tract infections caused by penicillin-susceptible S. pneumoniae TUH39a
| Antimicrobial agent | MICb (mg/ml) | ED50c(95% confidence limits) (mg/kg) |
|---|---|---|
| L-084 | 0.0005 | 1.95 (1.34–3.00) |
| Faropenem | 0.001 | >20 |
| Cefdinir | 0.125 | >20 |
| Cefditoren-pivoxil | 0.016 | >20 |
| Amoxicillin | 0.004 | >20 |
a
The challenge dose was 1.5 × 106 CFU/mouse, administered by intranesal instillation.
b
Broth microdilution method (inoculum size: 105 CFU/ml).
c
ED50s were calculated by the probit method based on the survival rate at 7 days after infection.