TABLE 3.

Therapeutic efficacy of L-084 and reference drugs against murine respiratory tract infection caused by penicillin-resistant S. pneumoniae TUM741

Drug	MIC (μg/ml)	Dosed (mg/kg)	Log CFU/lung (mean ± SD)
Control			7.36 ± 1.19
L-084	0.032	50	BDa
		10	2.53 ± 0.48b
Faropenem	0.25	50	6.72 ± 1.21
		10	7.90 ± 2.11
Cefditoren-pivoxil	0.25	50	6.93 ± 0.75
		10	8.42 ± 0.56
Cefdinir	2.0	50	6.74 ± 0.69
		10	7.45 ± 1.03
Amoxicillin	1.0	50	4.26 ± 0.70c
		10	7.21 ± 0.72

^aBD, below the lower limit of detection. 

^bP < 0.01 versus control and faropenem-, cefditoren-pivoxil-, cefdinir-, and amoxicillin-treated groups at the corresponding dose. 

^cP < 0.05 versus control and faropenem-, cefditoren-pivoxil-, and cefdinir-treated groups at the corresponding dose. 

^dDrugs were administered orally three times a day for 3 days.