TABLE 4.
Therapeutic efficacy of L-084 and reference drugs against murine respiratory tract infection caused by H. influenzae TUM8
| Drug | MIC (mg/ml) | Dosec (mg/kg) | Log CFU/lung (mean ± SD) |
|---|---|---|---|
| Control | 20 | 6.97 ± 1.01 | |
| 4 | 6.91 ± 0.97 | ||
| L-084 | 0.016 | 20 | 2.28 ± 0.01a |
| 4 | 2.57 ± 0.68b | ||
| Faropenem | 0.25 | 20 | 5.32 ± 1.75 |
| 4 | 5.25 ± 1.12 | ||
| Cefditoren-pivoxil | 0.002 | 20 | 2.28 ± 0.01a |
| 4 | 3.40 ± 0.43b | ||
| Cefdinir | 0.25 | 20 | 4.72 ± 0.50 |
| 4 | 6.09 ± 0.76 | ||
| Amoxicillin | 0.25 | 20 | 3.72 ± 1.27a |
| 4 | 5.95 ± 0.63 |
a
P < 0.05 versus control and faropenem- and cefdinir-treated groups at the corresponding dose.
b
P < 0.01 versus control and faropenem-, cefdinir-, and amoxicillin-treated groups at the corresponding dose.
c
Drugs were administered orally twice a day for 3 days.