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. 2022 Apr 13;14(8):1952. doi: 10.3390/cancers14081952

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PP2A activation resulted in a decrease in MYCN expression. (A) Immunoblotting was completed on whole cell lysates of SK-N-AS, and SK-N-BE(2) cells following treatment with increasing doses of 792 or 1154 for 24 h. Treatment with 792 and 1154 resulted in decreased MYCN expression in SK-N-BE(2) cells (right panel), while there was an increase in MYCN expression in SK-N-AS cells (left panel). (B) Immunoblotting was completed on whole cell lysates of two isogenic MYCN neuroblastoma cell lines, SH-EP (left panel) and WAC2 (right panel). Treatment with 792 or 1154 resulted in decreased MYCN expression. Vinculin was used as a loading control, and densitometry was used to quantify MYCN expression relative to vinculin expression. The uncropped western blot figures were presented in Figure S7.