TABLE 4.

Non-standardized regression coefficients (followed by 95% confidence intervals) of the mixed models predicting outcomes related to alcohol dependence.

	Cravings	SADD	Obsessive	Compulsive
	B (95% CI)	B (95% CI)	B (95% CI)	B (95% CI)
Time (reference = Screening)
First visit	−5.62 (−8.39; −2.85)	−10.77 (−14.92; −6.62)	−3.71 (−5.50; −1.93)	−12.17 (−14.71; −9.62)
Second visit	−7.25 (−10.26; −4.23)	−15.56 (−19.91; −11.2)	−5.67 (−7.64; −3.7)	−14.11 (−16.92; −11.31)
Third visit	−6.72 (−10.02; −3.41)	−19.35 (−24.12; −14.58)	−6.57 (−8.69; −4.45)	−15.41 (−18.41; −12.4)
Follow-up (6 months)	−4.85 (−8.99; −0.70)	−17.21 (−23.17; −11.25)	−6.74 (−9.29; −4.19)	−13.76 (−17.38; −10.15)
Group (reference = Omega-3)
Placebo	−1.33 (−4.06; 1.4)	−2.55 (−6.76; 1.66)	0.09 (−1.87; 2.06)	0.19 (−2.52; 2.9)
Time × Group
First visit	−2.26 (−6.34; 1.83)	−1.1 (−7.12; 4.92)	−3.22 (−5.88; −0.57)	−2.77 (−6.54; 1.01)
Second visit	−0.29 (−4.77; 4.2)	−2.47 (−8.91; 3.98)	−1.8 (−4.69; 1.09)	−0.9 (−5; 3.21)
Third visit	−0.17 (−4.91; 4.58)	0.93 (−5.93; 7.79)	−0.52 (−3.63; 2.59)	−0.64 (−5.07; 3.78)
Follow-up (6 months)	−0.93 (−6.7; 4.85)	−0.16 (−8.5; 8.17)	−0.5 (−4.11; 3.11)	−2.2 (−7.34; 2.93)

Mixed linear models.

In all models, time, group and interaction were included as fixed effects, the ID of the subject was included as a random effect, and education level and marital status were added as control variables.

SADD, Short Alcohol Dependence Data.