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. 2022 Mar 21;6(3):ytac105. doi: 10.1093/ehjcr/ytac105
Hour 0: Emergency room presentation Administration of metoprolol, amiodarone, and lidocaine for ventricular tachycardia (VT).
Hour 3 Sudden cardiac arrest from ventricular fibrillation with cardiopulmonary resuscitation (CPR) and return of spontaneous circulation.
Day 1 Transthoracic echocardiogram (TTE) demonstrated both global and regional depressed left ventricular (LV) function with ejection fraction of 45%.
Late gadolinium enhancement seen on cardiac magnetic resonance imaging in sub-epicardial regions of the LV.
Day 2 No further VT. Lidocaine infusion stopped.
Day 3 Endomyocardial biopsy showed lymphocytic myocarditis and scattered areas of myocyte hypertrophy and fibrosis.
Totally subcutaneous implantable cardioverter-defibrillator (S-ICD) implanted for secondary prevention.
Day 4 Discharge from hospital on oral amiodarone and metoprolol.
Month 3 Repeat TTE showed recovery of LV function with ejection fraction of 54%.
Cardiomyopathy gene panel revealed DSP truncation variant p. R1951X. This variant was also identified in the patient’s mother, who had a known cardiomyopathy.
Month 12 No ventricular arrhythmias recorded on S-ICD; no new symptoms. Patient continues on metoprolol and amiodarone.