Figure S1.

Clinical information and variant modelling. (A) Chest radiograph from P3 demonstrating pneumonitis and ARDS associated with influenza A infection. (B) Summary of the outputs of in silico prediction software. (C) Conservation of the p.Ser53Pro IFNAR2 residue across the indicated species. (D) Graphical models of the binary complex between human IFNα2 and IFNAR2 WT and p.Ser53Pro proteins (PDB accession no. 3S9D) were created using PyMOL software version 2.0.7. (E) Displayed are all rare exonic variants (gnomAD MAF < 0.01) in genes related to primary immunodeficiency identified by WGS in P1. All genotype quality scores were 99. CADD, Combined Annotation Dependent Depletion.