Scheme 1. Synthesis of (Aminomethyl)benzonitrile Derivatives.
(a) Phthalimide potassium salt, N,N-dimethylformamide (DMF), 9 h, 130 °C; (b) (i) N2H4·H2O, EtOH, reflux, and 2 h; (ii) HCl, Et2O, 0 °C, and 1 h; and (c) Boc2O, Et3N, CH3CN, rt, and 12 h.
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