Table 2.
Comparative analysis of the variation in polymorphisms of the SLC22A1 (rs202220802) and NUDT15 (rs1272632214) genes, by the occurrence of general toxicity, in patients with ALL of the Amazon Region.
| Polymorphisms | General Toxicity | p Value a | p Value b | OR (95%IC) | |
|---|---|---|---|---|---|
| Yes (n. 27) | No (n. 24) | ||||
| SLC22A1 | |||||
| n-n | 5 (18.5%) | 9 (37.5%) | 0.112 | 0.230 | 0.43 (0.11–1.69) |
| n-ins | 6 (22.2%) | 2 (8.3%) | 0.209 | 3.64 (0.51–20.63) | |
| n-del | 9 (33.3%) | 6 (25.0%) | 0.435 | 1.70 (0.45–6.51) | |
| del-ins | 1 (3.7%) | 5 (20.8%) | 0.072 | 0.12 (0.01–1.20) | |
| del-del | 5 (18.5%) | 1 (4.2%) | 0.196 | 4.68 (0.45–48.62) | |
| ins-ins | 1 (3.7%) | 1 (4.2%) | 0.635 | 0.50 (0.03–8.77) | |
| Allele n | 25 (46.3%) | 26 (54.2%) | 0.578 | 0.737 | 0.86 (0.37–2.01) |
| Allele ins | 9 (16.7%) | 9 (18.8%) | 0.502 | 0.68 (2.31–2.05) | |
| Allele del | 20 (37.0%) | 13 (27.1%) | 0.366 | 1.52 (0.61–3.77) | |
| NUDT15 | |||||
| Del-Del | 20 (76.9%) | 22 (91.7%) | 0.155 | 0.321 | 0.39 (0.06–2.64) |
| Ins-Del | 6 (23.1%) | 2 (8.3%) | |||
| Allele Del | 46 (88.5%) | 46 (95.8%) | 0.175 | 0.347 | 2.32 (0.40–13.55) |
| Allele Ins | 6 (11.5%) | 2 (4.2%) | |||
a Chi-square test. b Multivariate logistic regression adjusts for African ancestry. OR, odds ratio. CI, confidence interval.