Table 3.
Assessment of the diagnostic usefulness of selected biochemical and inflammatory markers, including the percentage of LDG and the LDG fraction showing MPO expression in the detection of LC in the course of AIH.
| Variable | Sensitivity (%) | Specificity (%) | Cut-Off Point | AUC [95%CI] | p |
|---|---|---|---|---|---|
| AST [IU/L] | 87.5 | 47.06 | >42 | 0.57 [0.35–0.76] | 0.5834 |
| ALT [IU/L] | 100 | 41.18 | ≤101 | 62.0 [0.41–0.81] | 0.2825 |
| GGTP [IU/L] | 87.5 | 47.06 | ≤122 | 0.63 [0.42–0.81] | 0.2767 |
| GPR | 87.5 | 31.25 | >0.4 | 0.58 [0.36–0.77] | 0.5590 |
| AAR | 87.5 | 56.25 | >0.84 | 0.73 [0.52–0.89] | 0.0349 * |
| APRI | 87.5 | 68.75 | >0.93 | 0.78 [0.56–0.92] | 0.0054 * |
| FIB-4 | 100 | 62.5 | >1.47 | 0.87 [0.67–0.97] | <0.0001 * |
| WBC [103/µL] | 100 | 75 | ≤6.2 | 0.91 [0.73–0.99] | <0.0001 * |
| PLT [103/µL] | 100 | 81.25 | ≤201.00 | 0.95 [0.78–0.99] | <0.0001 * |
| CRP [mg/mL] | 71.43 | 11.76 | >1.3 | 0.51 [0.30–0.72] | 0.9537 |
| LDG [%] | 50 | 93.75 | ≤0.25 | 0.75 [0.53–0.90] | 0.0391 * |
| LDG MPO+ [%] | 62.75 | 62.50 | ≤0.59 | 0.62 [0.41–0.81] | 0.3101 |
AAR—Aspartate aminotransferase—to-Alanine aminotransferase Ratio, APRI—Aspartate aminotransferase-to-Platelet Ratio Index, ALT—Alanine Aminotransferase, AST—Aspartate Aminotransferase, AUC—Area under curve, CD—Cluster of differentiation, CI—Confidence Interval, CRP—C-Reactive Protein, FIB-4—Fibrosis-4, GPR—Gamma-glutamyl-transpeptidase-to-Platelet Ratio, GGTP—Gamma Glutamyl Transpeptidase, LDG—Low Density Granulocytes, MPO—Myeloperoxidase, PLT—Platelet, WBC—White Blood Cells, *—statistically significant result.