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. 2022 Mar 28;11(4):651. doi: 10.3390/antiox11040651

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Aerobic exercise training reduced miRNAs-27a and -27b levels in a volume-dependent manner and increased angiotensin-converting enzyme 1 (ACE1) protein levels and activity in the soleus muscle: (A) miRNAs-27a and -27b expression; (B) ACE1 protein expression normalized for α-tubulin accompanied by its representative blot; (C) ACE1 activity. Negative correlation between the miRNA-27a and -27b expression and the ACE 1 protein levels (D) and (E), respectively. Groups: SC, sedentary control (n = 7); P1, swimming trained following protocol 1 (n = 7); P2, swimming trained following protocol 2 (n = 7). Each dot indicates a biological replication. Results are expressed as mean ± SEM. Statistical analysis: one-way ANOVA; correlation analysis was performed using Pearson’s method; significantly different vs. * SC, p < 0.05; ** SC, p < 0.01; *** SC, p < 0.001; **** SC, p < 0.0001; † P1, p < 0.05.