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Selected independent and dependent variables used to optimize AGN-PLHNPs by the 33-BBD.
| Independent Variables | Low (−1) | Medium (0) | High (+1) |
|---|---|---|---|
| F1 = Concentration of PLGA (mg/mL) | 7 | 9 | 11 |
| F2 = Concentration of PL-90G (mg/mL) | 5 | 7 | 9 |
| F3 = Concentration of P-188 (%) | 0.75 | 1.00 | 1.25 |
| Dependent variables | Goal | ||
| R1 = Particle size (PS; nm) | Minimize | ||
| R2 = Entrapment efficiency (EE; %) | Maximize | ||
| R3 = Cumulative drug release (CDR; %) | Maximize | ||
