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. 2022 Mar 27;14(4):720. doi: 10.3390/pharmaceutics14040720

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Different molecular images (top: axial sections; bottom: PET/CT or SPECT/CT images) of a patient with multiple colorectal liver metastases (PSMA-positive): (a) [¹⁸F]FDG PET/CT images acquired on 27 August 2021; [^99mTc]Tc-iPSMA SPECT/CT images at (b) 3 h and (c) 24 h post-injection (administration on 9 November 2021); and (d) ¹⁷⁷Lu₂O₃-iPSMA SPECT/CT images acquired on 18 November 2021. It can also be observed that over almost three months, the metastases moved due to the appearance of bilomas and the presence of necrotic tumors. The ¹⁷⁷Lu₂O₃-iPSMA SPECT/CT image was contrast-enhanced to highlight the uptake of the radionanoparticles in tumor lesions as proof of concept. The detailed biokinetic behavior of the source organs is shown in Figure 6.