Table 4.
Biodistribution (% injected dose) at various time points of 177Lu2O3-iFAP in nude mice bearing HCT116 tumors (mean ± SD) (n = 3), after intratumoral injection.
| Tissue | Time (h) | |||
|---|---|---|---|---|
| 3 | 48 | 72 | 96 | |
| Heart | 0.22 ± 0.09 | 0.18 ± 0.09 | 0.14 ± 0.07 | 0.05 ± 0.02 |
| Lung | 0.26 ± 0.11 | 0.19 ± 08 | 0.16 ± 0.05 | 0.10 ± 0.04 |
| Liver | 1.18 ± 0.70 | 1.10 ± 0.42 | 0.83 ± 0.22 | 0.81 ± 0.13 |
| Spleen | 0.40 ± 0.14 | 0.35 ± 0.12 | 0.32 ± 0.11 | 0.26 ± 0.09 |
| Kidney | 0.91 ± 0.17 | 0.78 ± 0.15 | 0.62 ± 0.13 | 0.50 ± 0.18 |
| Tumor (%ID/g) | 83.87 ± 5.33 | 81.21 ± 5.64 | 78.58 ± 3.81 | 77.32 ± 4.25 |