Table 2.
Genotype distribution of SORL1 variants with Alzheimer’s disease in Mexican samples.
| Polymorphisms | Genotype Frequency (%) |
HWE
p |
Model Inheritance | |||||
|---|---|---|---|---|---|---|---|---|
| rs668387 | C/C | T/T | T/C | p | OR (95%) | |||
| Controls (n = 221) | 68 (30.8) | 39 (17.6) | 114 (51.6) | 0.459 | G/G vs. A/A+A/G | 0.976 | 1.007 (0.640–1.584) | |
| Cases (n = 156) | 47 (30.1) | 24 (15.4) | 85 (54.5) | 0.155 | G/G+A/G vs. A/A | 0.758 | 1.093 (0.621–1.923) | |
| G/A vs. G/G+A/A | 0.84 | 1.044 (0.687–1.587) | ||||||
| rs689021 | G/G | A/A | G/A | |||||
| Controls (n = 221) | 66 (29.9) | 39 (17.6) | 116 (52.5) | 0.329 | C/C vs. T/T+C/T | 0.713 | 1.089 (0.692–1.714) | |
| Cases (n = 156) | 48 (30.8) | 23 (14.7) | 85 (54.5) | 0.139 | C/C+C/T vs. T/T | 0.62 | 1.155 (0.653–2.045) | |
| C/T vs. C/C+T/T | 0.978 | 1.006 (0.662–1.530) | ||||||
| rs641120 | C/C | T/T | C/T | |||||
| Controls (n = 221) | 68 (30.8) | 38 (17.2) | 115 (52.0) | 0.37 | C/C vs. T/T+C/T | 0.743 | 1.078 (0.687–1.692) | |
| Cases (n = 156) | 49 (31.4) | 23 (14.7) | 84 (53.8) | 0.179 | C/C+C/T vs. T/T | 0.657 | 1.139 (0.642–2.019) | |
| C/T vs. C/C+T/T | 0.981 | 1.005 (0.661–1.527) | ||||||
| rs2070045 | G/G | T/T | G/T | |||||
| Controls (n = 221) | 68 (30.8) | 50 (22.6) | 103 (46.6) | 0.359 | T/T vs. G/G+G/T | 0.766 | 1.078 (0.659–1.762) | |
| Cases (n = 156) | 42 (26.9) | 38 (24.4) | 76 (48.7) | 0.755 | T/T+G/T vs. G/G | 0.469 | 1.186 (0.748–1.880) | |
| G/T vs. G/G+T/T | 0.684 | 1.090 (0.719–1.653) | ||||||
| rs3824966 | C/C | G/G | C/G | |||||
| Controls (n = 221) | 54 (24.4) | 65 (29.4) | 102 (46.2) | 0.267 | C/C vs. G/G+C/G | 0.869 | 1.041 (0.644–1.684) | |
| Cases (n = 156) | 40 (25.6) | 42 (26.9) | 74 (47.4) | 0.523 | C/C+C/G vs. G/G | 0.635 | 1.119 (0.704–1.778) | |
| C/G vs. C/C+G/G | 0.775 | 1.063 (0.701–1.612) | ||||||
| rs1699102 | C/C | T/T | C/T | |||||
| Controls (n = 221) | 103(46.6) | 26 (11.8) | 92 (41.6) | 0.436 | T/T vs. C/C+C/T | 0.221 | 1.454 (0.799–2.647) | |
| Cases (n = 156) | 62 (39.7) | 26 (16.7) | 68 (43.6) | 0.323 | T/T+C/T vs. C/C | 0.181 | 1.334 (0.874–2.036) | |
| C/T vs. T/T+C/C | 0.626 | 1.110 (0.729–1.690) | ||||||
| rs3824968 | A/A | T/T | A/T | |||||
| Controls (n = 221) | 65 (29.4) | 47 (21.3) | 109 (49.3) | 0.917 | T/T vs. A/A+A/T | 0.497 | 1.187 (0.724–1.946) | |
| Cases (n = 156) | 41 (26.3) | 38 (24.4) | 77 (49.3) | 0.876 | T/T+A/T vs. A/A | 0.626 | 1.123 (0.704–1.791) | |
| A/T vs. T/T+A/A | 0.895 | 0.972 (0.642–1.474) | ||||||
| rs2282649 | C/C | T/T | C/T | |||||
| Controls (n = 221) | 52 (23.5) | 65 (29.4) | 104 (47.1) | 0.409 | C/C vs. T/T+C/T | 0.695 | 1.101 (0.680–1.783) | |
| Cases (n = 156) | 41 (26.3) | 39 (25.0) | 76 (48.7) | 0.75 | C/C+C/T vs. T/T | 0.482 | 1.184 (0.739–1.896) | |
| C/T vs. C/C+T/T | 0.773 | 1.063 (0.702–1.611) | ||||||
| rs1010159 | G/G | A/A | A/G | |||||
| Controls (n = 221) | 71 (32.1) | 50 (22.6) | 100 (45.2) | 0.197 | A/A vs. G/G+A/G | 0.053 | 1.590 (0.995–2.541) | |
| Cases (n = 156) | 43 (27.6) | 49 (31.4) | 64 (41.0) | 0.026 | A/A+A/G vs. G/G | 0.359 | 1.239 (0.784–1.956) | |
| A/G vs. A/A+G/G | 0.381 | 0.829 (0.544–1.262) | ||||||
| rs1784933 | A/A | G/G | A/G | |||||
| Controls (n = 221) | 71 (32.1) | 50 (22.6) | 100 (45.2) | 0.197 | A/A vs. G/G+A/G | 0.03 | 1.608 (1.046–2.473) | |
| Cases (n = 156) | 68 (43.6) | 24 (15.4) | 64 (41.0) | 0.175 | A/A+A/G vs. G/G | 0.123 | 1.538 (0.890–2.656) | |
| A/G vs. A/A+G/G | 0.38 | 0.828 (0.544–1.261) | ||||||
| APOE | APOEε4 non carriers | APOEε4 carriers | ||||||
| Controls (n = 221) | 188 (85.1) | 33 (14.9) | ε4 carriers vs. Non carriers |
0.000 | 3.630 (2.195–6.004) | |||
| Cases (n = 156) | 98 (62.8) | 58 (37.2) | ||||||
Logistic regression adjusting for sex and age.