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. 2022 Mar 24;11(4):397. doi: 10.3390/pathogens11040397

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Receiver-operating characteristic (ROC) curves, constructed using 78 NELF samples, with both IgA and NAb levels measured. The area under the curve (AUC) was 0.80 with p < 0.001. Using the ROC curve, the threshold for NELF IgA was defined as > 4.386 by the Youden index calculation. Using this cutoff value, the sensitivity and specificity were 98.11% and 94.44%, respectively, with an accuracy of 97.18%. (B) All the available CT values of the paediatric patients who showed NELF IgA levels above and below the thresholds level are plotted against time. For this panel data, a fixed-effect regression model was applied to compare the changes of the CT values across time between these 2 groups. A statistically significant difference was found in the decline rate of the viral load at p = 0.002.

Inline graphic — (A) Receiver-operating characteristic (ROC) curves, constructed using 78 NELF samples, with both IgA and NAb levels measured. The area under the curve (AUC) was 0.80 with p < 0.001. Using the ROC curve, the threshold for NELF IgA was defined as > 4.386 by the Youden index calculation. Using this cutoff value, the sensitivity and specificity were 98.11% and 94.44%, respectively, with an accuracy of 97.18%. (B) All the available CT values of the paediatric patients who showed NELF IgA levels above and below the thresholds level are plotted against time. For this panel data, a fixed-effect regression model was applied to compare the changes of the CT values across time between these 2 groups. A statistically significant difference was found in the decline rate of the viral load at p = 0.002.