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. 2022 Mar 15;63(5):100195. doi: 10.1016/j.jlr.2022.100195

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Effect of HSL deletion on bioactive lipids. A: A panel of bioactive lipids analyzed by targeted mass spectrometry allowed to discriminate between HSL^+/+ and HSL^−/− mice in a PLS-DA (six males and five females for HSL^+/+; two males and seven females for HSL^−/−). PC1 and PC2 accounted for 32% and 36% of the total variance. Ellipsoids represent SD. B and C: Volcano plots showing VIP for the PLS regression versus relative change in HSL^−/− versus HSL^+/+. Lipids in the hippocampus (B) and cortex (C) with VIP >1 are labeled and highlighted in yellow. For complete metabolite abbreviations and concentrations, see supplemental Tables S2 and S3. PC1, principal component 1; PC2, principal component 2.